Another week, another try! Vadim and I both performed a labyrinthectomy. Not entirely succesful but not completely disappointing either. Vadim's mouse survived but needed a second shot of anesthesia during the procedure. It is now having some trouble coming out of it, but it's still alive so it looks hopeful. I was a little less lucky. The procedure went great and fast enough. Unfortunately the animal died during the procedure. That can happen, it's just very annoying that we don't know why it died. It didn't bleed at all and we were supposedly on the safe side with our dose of anesthesia. We'll just try again tomorrow and if Vadim's mouse survives we might do some recording. So work is in progress, we're getting better and succes is close... I'll keep you posted..
Monday, September 26, 2005
Today's surgery attempt
Another week, another try! Vadim and I both performed a labyrinthectomy. Not entirely succesful but not completely disappointing either. Vadim's mouse survived but needed a second shot of anesthesia during the procedure. It is now having some trouble coming out of it, but it's still alive so it looks hopeful. I was a little less lucky. The procedure went great and fast enough. Unfortunately the animal died during the procedure. That can happen, it's just very annoying that we don't know why it died. It didn't bleed at all and we were supposedly on the safe side with our dose of anesthesia. We'll just try again tomorrow and if Vadim's mouse survives we might do some recording. So work is in progress, we're getting better and succes is close... I'll keep you posted..
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Today's try was a complete succes! The entire procedure took 1h and 45 minutes and we needed to give a second shot of anesthesia. But I managed to get everything out and coagulated the stapedial arterie just fine, filled the oval window with neurotoxin and with three stitches and and some antibiotic the mouse should be fine. But you never know it for sure until the next day. Now (2h later) he 's still breathing and the anesthesia is slowly wearing off. We'll have to see if he makes it till tomorrow...
ReplyDeleteA day later the mouse is still alive, but doesn't seem to be very affected by the labyrinthectomy. That's good news for the mouse, but not for us.. The arsenic acid may need some more time to do its degenerative actions, so it might be alright. I am going to do one today and I'll make sure I'll do some mechanical damage before injecting the toxin into the oval window. That will probably have more effect. It did on Vadim's mouse...
ReplyDeleteAnd the clock stops at 1h today. The experience pays off! Now let's see how severe the effects will be this time....
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